Lectures
Orlando C Hall
28.9.2025
17:00 – 18:10h
Opening
Welcome address
Ita Gruic-Sovulj and Lluis Ribas de Pouplana
17:00h - 17:20h
Lectures
Orlando C Hall
28.9.2025
17:00 – 18:10h
Opening
FEBS Introduction
Zrinka Kovarik
17:20h - 17:40h
Lectures
Orlando C Hall
28.9.2025
17:00 – 18:10h
Opening
Paul Schimmel
17:40h - 18:10h
Lectures
Orlando C Hall
29.9.2025
09:15 – 10:25h
Canonical Biochemistry 1
Surprising enzymatic activity of OB-fold containing multi-aminoacyl-tRNA synthetase adaptor proteins
Karin Musier-Forsyth
09:15h - 09:35h
Lectures
Orlando C Hall
29.9.2025
09:15 – 10:25h
Canonical Biochemistry 1
Chiral discrimination and metal ion mediated translation quality control in Alanyl-tRNA synthetase
Shobha Kruparani Polarumi
09:35h - 09:50h
Lectures
Orlando C Hall
29.9.2025
09:15 – 10:25h
Canonical Biochemistry 1
Decoding Zinc Domain Dynamics and Function in Leucyl-tRNA Synthetase
Guillaume Hoffmann
09:50h - 10:05h
Lectures
Orlando C Hall
29.9.2025
09:15 – 10:25h
Canonical Biochemistry 1
Osamu Nureki
10:05h - 10:25h
Lectures
Orlando C Hall
29.9.2025
08:30 – 09:15h
EMBO Keynote Lecture
Ribosome Upside Down: Co-translational Protein Biogenesis at the Tunnel Exit
Nenad Ban
08:30h - 09:15h
Lectures
Orlando C Hall
29.9.2025
11:25 – 13:00h
Canonical Biochemistry 2
Is Speed the Key? Exploring Divergence in Bacterial tRNAIle Recognition
Ita Gruic-Sovulj
11:25h - 11:45h
Lectures
Orlando C Hall
29.9.2025
11:25 – 13:00h
Canonical Biochemistry 2
Chiral proofreaders, their variants and their functional roles
Rajan Sankaranarayanan
11:45h - 12:05h
Lectures
Orlando C Hall
29.9.2025
11:25 – 13:00h
Canonical Biochemistry 2
Coexisting tryptophanyl-tRNA synthetases endow a human microbial pathogen with distinct fitness advantage
Oscar Vargas-Rodriguez
12:20h - 12:35h
Lectures
Orlando C Hall
29.9.2025
15:00 – 16:40h
Evolution
Pre-LUCA protein evolution
Klara Hlouchova
15:00h - 15:20h
Lectures
Orlando C Hall
29.9.2025
15:00 – 16:40h
Evolution
Phylogenetic reconstruction of ancestral coding alphabets using aaRS sequences
Jordan Douglas
15:20h - 15:35h
Lectures
Orlando C Hall
29.9.2025
15:00 – 16:40h
Evolution
Structural Modularity, Functional Information, and the Genesis of Genetic Coding
Charlie Carter
15:50h - 16:05h
Lectures
Orlando C Hall
29.9.2025
15:00 – 16:40h
Evolution
A Catalytic Pathway to Support Prebiotic Linkage Between Amino Acids and RNA
Joshua Maiklem
15:35h - 15:50h
Lectures
Orlando C Hall
29.9.2025
15:00 – 16:40h
Evolution
Historical reconstruction of the glutamate-to-glutamine specificity switch in a resurrected ancient aminoacyl-tRNA synthetase
Aleksandar Radakovic
16:05h - 16:20h
Lectures
Orlando C Hall
29.9.2025
17:10 – 18:55h
Fidelity
Homocysteine thiolactone from translation proofreading is an endogenous ligand for cell-cell signaling by the receptor SdiA
Lorenzo Leiva
17:10h - 17:30h
Lectures
Orlando C Hall
29.9.2025
17:10 – 18:55h
Fidelity
Proteomic profiling of isoleucine mistranslation in Escherichia coli
Marko Mocibob
17:30h - 17:45h
Lectures
Orlando C Hall
29.9.2025
17:10 – 18:55h
Fidelity
An Openly Available Toolbox for the Study of tRNA Synthetases
Yinuo Wang
17:45h - 18:00h
Lectures
Orlando C Hall
29.9.2025
17:10 – 18:55h
Fidelity
Drive Genetic Code Expansion with a Dual Fluorescent Reporter and FACS-Based Selection of Functional Aminoacyl-tRNA Synthetases
Arshia Arasteh Kani
18:00h - 18:15h
Lectures
Orlando C Hall
29.9.2025
17:10 – 18:55h
Fidelity
Engineering translation machinery for production of post-translationally modified selenoproteins in E. coli
Natalie Krahn
18:15h - 18:30h
Vacuolar echoforms of yeast cytosolic aminoacyl-tRNA synthetases are modulating components of TORC1
Hubert Becker
09:15h - 09:35h
Unknown role of arginyl-tRNA synthetase paralogue with a variation in the HIGH motif
Igor Zivkovic
09:35h - 09:50h
Noncanonical functions of mitochondria-relocated cytosolic aminoacyl-tRNA synthetases in health and disease
Sandrine Serre
09:50h - 10:05h
WHEP Domain of Glycyl-tRNA Synthetase Regulates Neuropilin 1 Binding and Vascular Permeability
Xiang-Lei Yang
10:05h - 10:25h
Lectures
Orlando C Hall
30.9.2025
08:30 – 09:15h
Keynote Lecture
RNA condensates at the nexus of cellular stress, disease and aging
Simon Alberti
08:30h - 09:15h
Lectures
Orlando C Hall
28.9.2025
18:10 – 18:55h
IUBMB Keynote Lecture
Hiroaki Suga
18:10h - 18:55h
Role of aminoacyltRNA synthetases in oxidative stress response
Jasmina Rokov-Plavec
11:25h - 11:45h
Probing secretion mechanism and topology of extracellular glycyl-tRNA synthetase
Jiadong Zhou
11:45h - 12:00h
The tRNA Multisynthetase Complex is Critical for the Cardiac Response to Stress
Vasundhara Singh
12:00h - 12:15h
Investigating the Scope of Thioester-Mediated Aminoacylation of RNA with Non-Canonical Amino Acids
Jacob Sebastian Lindqvist Muci
12:15h - 12:30h
Embracing chaos: fluctuations of protein synthesis in single bacterial cells
Jiqiang Ling
12:30h - 12:50h
How the analysis of pathology-related variants shed light on fundamental process: the case of PARS2 variants
Marie Sissler
09:15h - 09:35h
Drosophila models of histidyl-tRNA synthetase-associated peripheral neuropathy
Maria Menafra
09:35h - 09:50h
Engineered LysRS Switches: Uncoupling Translation from Ap4A Signaling with Therapeutic Implications
Santiago Movilla
09:50h - 10:05h
The nuclear function of TyrRS as a mediator of stress response in the CharcotMarieTooth neuropathy
Albena Jordanova
10:05h - 10:25h
Lectures
Orlando C Hall
1.10.2025
08:30 – 09:15h
Keynote Lecture
Mitochondrial tRNA synthetase disorders: moving towards therapy
Rita Horvath
08:30h - 09:15h
tRNA-based therapies: roadblocks en route to their establishment as treatment for diverse pathologies
Zoya Ignatova
11:00h - 11:20h
tRNA and amino acid supplementation rescues mistranslation caused by pathogenic HARS alleles
Ilka Heinemann
11:20h - 11:35h
Leslie Nangle
Advancing a Therapeutic Platform Based on tRNA Synthetases for Treatment of Fibrotic Lung Diseases
15:15h - 15:35h
Fluorescent Probe-Based Mechanistic Insights into Kinetoplastida-tRNA Synthetase for Drug Target Validation
Pratyasha Bhowal
15:35h - 15:50h
Structural Studies on Protein–RNA complexes and Applications for the Development of Novel Therapeutics
Andrés Palencia
15:50h - 16:10h
Leucyl-tRNA synthetase as a therapeutic target for Duchenne muscular dystrophy
Jie Chen
16:10h - 16:25h
Hijacking aminoacyl-tRNA synthetases: a new strategy for development of anti-infectives
Leann Tilley
16:25h - 16:40h
Peptide-Aminoacyl-tRNA Ligases in Natural Product Biosynthesis
Wilfred van der Donk
17:10h - 17:30h
Nanopore sequencing of intact aminoacylated tRNAs
Jay Hesselberth
17:30h - 17:45h
Genetic code expansion as a tool for the development of novel protein-based nanosensors
Ana Crnkovic
17:45h - 18:05h
Synergistic genetic and chemical approaches to expand the molecular diversity of phagedisplayed peptide libraries
Jeffery Tharp
18:05h - 18:25h
Predictive modeling to define the locus heterogeneity of tRNA synthetase-related peripheral neuropathy
Allison Cale
18:25h - 18:40h
From Mechanism to Optimized Inhibitors with Enhanced Selectivity Targeting Threonyl-tRNA Synthetase
Pengfei Fang
18:40h - 18:55h
Lectures
Orlando C Hall
2.10.2025
09:15 – 10:25h
Transfer RNA 1
Natural and therapeutic human transfer RNA anticodon variants
Patrick O'Donoghue
09:15h - 09:35h
Lectures
Orlando C Hall
2.10.2025
09:15 – 10:25h
Transfer RNA 1
Mechanisms and therapeutic applications of transfer RNA
Chris Ahern
09:35h - 09:50h
Lectures
Orlando C Hall
2.10.2025
09:15 – 10:25h
Transfer RNA 1
Expanding Ribosomal Catalysis via Non-Canonical Monomers
Joongoo Lee
09:50h - 10:05h
Lectures
Orlando C Hall
2.10.2025
09:15 – 10:25h
Transfer RNA 1
Somatic tRNA Mutations Are Abundant and Rewire the Genetic Code in Cancer and Aging
Lluís Ribas de Pouplana
10:05h - 10:25h
Lectures
Orlando C Hall
2.10.2025
08:30 – 09:15h
Keynote Lecture
Expanding the Proteasome Paradigm: Uncovering the Independent Roles of the 20S Core Complex
Michal Sharon
08:30h - 09:15h
Lectures
Orlando C Hall
2.10.2025
11:25 – 13:00h
Transfer RNA 2
Ribosome Selection of Wobble-Modified Aminoacyl-tRNA Exclusively by Proofreading
Ya-Ming Hou
11:25h - 11:45h
Lectures
Orlando C Hall
2.10.2025
11:25 – 13:00h
Transfer RNA 2
Exclusion of Arginyl-tRNA synthetase from the multisynthetase complex causes defects in brain development
Haissi Cui
11:45h - 12:05h
Lectures
Orlando C Hall
2.10.2025
11:25 – 13:00h
Transfer RNA 2
Temperature Sensitivity of Aminoacyl-tRNA Synthetase Variants and Its Implications for Disease
Marisa Mendes
12:05h - 12:20h
Lectures
Orlando C Hall
2.10.2025
11:25 – 13:00h
Transfer RNA 2
Ultra-sensitive sequencing reveals extensive tRNA dynamics during cell differentiation
Ru-Juan Liu
12:20h - 12:40h
Lectures
Orlando C Hall
2.10.2025
11:25 – 13:00h
Transfer RNA 2
Novel AIMP2 mutations cause neurodevelopmental defects through a loss-of-function mechanism linked to cell death in the developing zebrafish brain
Christopher Francklyn
12:40h - 13:00h
Lectures
Orlando C Hall
2.10.2025
15:00 – 16:55h
Disease
Development of A Unique Domain Embedded in tRNA Synthetase for Cancer Therapy
Sunghoon Kim
15:00h - 15:20h
Lectures
Orlando C Hall
2.10.2025
15:00 – 16:55h
Disease
Mammalian leucyl-tRNA synthetase from liver cancer cells modulates cellular senescence and autophagy
Susan Martinis
15:20h - 15:40h
Lectures
Orlando C Hall
2.10.2025
15:00 – 16:55h
Disease
Elucidating the Role of Human Multi-Aminoacyl-tRNA Synthetase Complex (MSC) in Hypomyelination with Brainstem and Spinal Cord Involvement and Leg Spasticity (HBSL)
Bahaa Al-Mhanawi
15:40h - 15:55h
Lectures
Orlando C Hall
2.10.2025
15:00 – 16:55h
Disease
tRNA Optimality as a Determinant of Cancer Stemness in Colorectal Tumors
Francesca Rapino
15:55h - 16:15h
Lectures
Orlando C Hall
2.10.2025
15:00 – 16:55h
Disease
Therapeutic Potential of an Anti-KARS1 Antibody Blocking Monocyte Migration in PAH Models
Nam Hoon Kwon
16:15h - 16:35h
Lectures
Orlando C Hall
2.10.2025
15:00 – 16:55h
Disease
tRNA modifications: a new vulnerability driving cancer heterogeneity & tumor immune response
Pierre Close
16:35h - 16:55h
Lectures
Orlando C Hall
2.10.2025
17:30 – 18:30h
Closing
EPRS1 goes nuclear
Paul Fox
17:30h - 18:00h
Lectures
Orlando C Hall
2.10.2025
17:30 – 18:30h
Closing
Prizes and closing
Ita Gruic-Sovulj and Lluis Ribas de Pouplana
18:00h - 18:30h
Lectures
Orlando C Hall
29.9.2025
11:25 – 13:00h
Canonical Biochemistry 2
Abhishek Chaterjee
Virus-assisted directed evolution of nonsense suppressor tRNAs in mammalian cells
12:05h - 12:20h